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Amitriptyline inhibits SCN5A. 3 / 3

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"Block of human heart hH1 sodium channels by amitriptyline."

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"Amitriptyline induced a similar use-dependent block of Nav1.5 as was determined duloxetine (1 µM 33±0.5%; 10 µM 84±4%; n=11; Fig. 2 D)."

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"Saying this, it is possible that our investigations on inactivated Nav1.5 channels at −70 mV much better represents the physiological condition than the recordings on resting channels at −120 mV.The p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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Statements

Amitriptyline inhibits SCN5A. 3 / 3

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