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BAP1 ubiquitinates H2Aub. 3 / 3
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"Specifically, our study suggests a model in which the tumor suppressor BAP1 normally functions to repress the expression of SLC7A11 at least partly by deubiquitinating H2Aub on SLC7A11, thereby inhibiting cystine uptake into cells and rendering them more sensitive to ferroptosis."
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"Previous studies also investigated that BAP1 links ferroptosis to tumor suppression by repressing SLC7A11 expression through BAP1-mediated H2Aub deubiquitination on SLC7A11 in PDAC cells12."
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"A recent study reported that BAP1 inhibits cystine uptake and makes cells more susceptible to ferroptosis by deubiquitinating H2Aub on SLC7A11."
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