IndraLab

Statements

USP25 activates Ubiquitin. 4 / 4
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"Deletion of one or both UIM domains of USP25 does not alter C-terminal processing activity but strongly impairs K48 and K63 ubiquitin chain cleavage."
18538659
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"To further identify which Ub linkage type is targeted by USP25 in vivo, HEK-293T cells were transfected with HA-K48-Ub or HA-K63-Ub in lieu of HA-Ub."
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"Interestingly, we observed the opposite pattern with USP21, which rescued ubiquitin availability but was unable to rescue degradation of our panel of substrates."
33417828
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"Additionally USP21 may target not only ubiquitin conjugated substrates but also substrates conjugated to ubiquitin like proteins ISG15 and NEDD8 (Gong et al., 2000; Ye et al., 2011)."
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