IndraLab

Statements

USP25 activates Ubiquitin. 4 / 4
| 4
reach
"Additionally USP21 may target not only ubiquitin conjugated substrates but also substrates conjugated to ubiquitin like proteins ISG15 and NEDD8 (Gong et al., 2000; Ye et al., 2011)."
24647359
reach
"Interestingly, we observed the opposite pattern with USP21, which rescued ubiquitin availability but was unable to rescue degradation of our panel of substrates."
33417828
reach
"To further identify which Ub linkage type is targeted by USP25 in vivo, HEK-293T cells were transfected with HA-K48-Ub or HA-K63-Ub in lieu of HA-Ub."
24260525
reach
"Deletion of one or both UIM domains of USP25 does not alter C-terminal processing activity but strongly impairs K48 and K63 ubiquitin chain cleavage."
18538659