IndraLab

Statements

CDK1 binds USP33. 7 / 7
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"CDK1 binds and phosphorylates USP33 at Ser650 and Ser843."
40695806
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"Specifically, we demonstrate a previously uncharacterized tumor-promoting activity of the CDK1–USP33 axis in PDAC through stabilizing SIN1, a key mediator of mTORC2-AKT activation."
40695806
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"In conclusion, our study provides compelling preclinical evidence that targeting the CDK1–USP33 axis may effectively destabilize SIN1, thereby inhibiting tumor growth and overcoming gemcitabine resistance in PDAC."
40695806
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"Moreover, our preclinical data demonstrate that targeting the CDK1-USP33 axis effectively suppresses tumor progression in PDAC via destabilizing SIN1 (Fig. xref )."
40695806
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"Our results provide compelling preclinical evidence that targeting the CDK1–USP33 axis may offer a promising therapeutic strategy to destabilize SIN1 and overcome chemoresistance in PDAC and potentially other aggressive cancers."
40695806
sparser
"First, we demonstrate that CDK1 binds and phosphorylates USP33 at Ser650 and Ser843, and the phosphorylation-deficient 2A mutation of USP33 failed to undergo phosphorylation (Fig. xref and Supplementary Fig. xref )."
40695806
sparser
"In a cell-free system, purified GST-USP33, but not GST or GST-SIN1 protein, bound to His-CDK1, suggesting a direct interaction between CDK1 and USP33 (Fig. xref )."
40695806