IndraLab

Statements

KCNH2 inhibits INS. 5 / 5
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"Pharmacological Kv11.1 blockade (dofetilide) in rats had similar effects and inhibition of hERG in beta and L cells directly increased insulin and GLP-1 secretion up to 50%."
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"Selective blockage of hERG K + channels increased firing frequency and insulin secretion in human beta cells."
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"In the latter extensive study, inhibition of herg channels was shown to have mechanistically distinct, but physiologically complementary, functions to enhance insulin secretion from beta cells and inhibit glucagon secretion from alpha-cells."
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"Pharmacological Kv11.1 blockade (dofetilide) in rats had similar effects and inhibition of hERG in beta and L cells directly increased insulin and GLP-1 secretion by up to 50%."
28235848
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"We also show that inhibition of hERG directly increases secretion of both insulin and GLP-1 from cultured beta and L cells, respectively."
28235848