IndraLab

Statements

MTX1 activates TNFAIP3. 4 / 4
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"By contrast, TNFAIP3 induction by MTX was observed in all donors examined."
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"MTX induces upregulation of the TNFAIP3 gene, which encodes for the protein A20, a negative regulator of NFkappaB signaling."
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"TNFAIP3 induction by MTX was inhibited by the simultaneous addition of FA, indicating that MTX triggered TNFAIP3 induction relies on blocking one-carbon metabolism (XREF_FIG)."
29431121
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"XREF_BIBR Assessment of the underlying mechanism revealed that MTX triggered TNFAIP3 induction in GM-MO was significantly diminished (40%) after TS silencing with two different small interfering RNA (XREF_FIG), thus indicating that MTX triggered TNFAIP3 upregulation is partly dependent on TS expression."
29431121