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OTUD5 leads to the deubiquitination of MYD88 on K250. 2 / 2

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"Notably, OTUD5 abrogates K11-linked polyubiquitination of MyD88 at Lys95, Lys231 and Lys250, which subsequently promotes MyD88 oligomerization and the assembly of Myddosome."

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"The Co-IP analysis showed that OTUD5 inhibited polyubiquitination of MyD88 (WT) and its mutants MyD88 (K95), MyD88 (K231), and MyD88 (K250) in HEK293T cells (Fig. 3G)."

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IndraLab

Statements

OTUD5 leads to the deubiquitination of MYD88 on K250. 2 / 2

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