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Quercetin inhibits FOS. 7 / 7
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"Western blotting showed that siRNA mediated inhibition of PPAR-gamma transcription led to an increase in AP-1 (c-fos, c-jun) protein expression in H9C2 cells, indicating that quercetin, at least in part, deregulates c-fos and c-jun via the PPAR-gamma signaling pathway."
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"Lagarrigue et al. showed that the flavonoid quercetin could inhibit the transformation of the rat liver epithelial cell line overexpressing c-Fos, suggesting that regulation of c-Fos/AP-1 complexes mi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Mechanistically, quercetin reduces CGRP, immunoreactive C-fos cells, and other inflammatory factors involved in the development of migraine headaches."
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"By contrast, the addition of 50 μM quercetin alone increased the induction of c-Jun and Fra-2, and inhibited the induction of c-Fos or Fra-1."
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"We hypothesized that quercetin mediated inhibition of cardiac hypertrophy would be accompanied by increased activation of PPAR-gamma and reduced activation of AP-1 (c-fos, c-jun) both in vivo and in vitro."
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"Furthermore, the study showed that quercetin, quercetin nanoemulsion, and rutin decreased the nociceptive biomarker c-Fos in the spinal cord, indicating that phytochemicals modulated the oxaliplatin-induced neuropathy at the central level [58]."
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"For instance, in primary culture of astrocytes, quercetin inhibits expression of three HSPs—c-fos protein, HSP70 and glial fibrillary acidic protein (GFAP)—which are involved in injury response."
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