IndraLab

Statements

USP25 activates FOXP3. 4 / 4
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"USP21 prevents FOXP3 degradation through deubiquination, thus stabilizing Treg phenotype and antagonizing the development of Th1 like Tregs [XREF_BIBR]."
28624966
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"From our previous data, E3 deubiquitinase USP21 prevents the depletion of FOXP3 and restricts the generation of Th1-like Treg cells ."
38167862
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"Similarly, USP21 prevents Foxp3 degradation by deubiquitinating K48-type modifications at residues Lys 206, Lys 216, Lys 227, Lys 252, Lys 277, Lys 332, and Lys 393."
33912156
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"T cells from the dKO mice displayed a GSEA and bulk gene expression signature that merged the changes found in each of the single KO mice, suggesting that the loss of both Usp22 and Usp21 synergizes to diminish T cell function (Fig. 4G) in both Foxp3-depedent and Foxp3-independent manner.As we demonstrated that both Usp22 and Usp21 are regulated by metabolic alterations in the TME, it was particularly interesting to identify disruption of multiple metabolic pathways in each of the KO groups."
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