IndraLab

Statements

SGK1 activates KCNH2. 5 / 5
| 5
reach
"HERG channel activity is up-regulated by the serum- and glucocorticoid inducible kinase isoforms SGK1 and SGK3."
23735862
reach
"Consistent with the above observations, our data indicated that SGK1 activator effectively prevented nilotinib or vandetanib-induced the downregulation of hERG channels, thereby significantly reducing[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35680041
reach
"XREF_BIBR It has been demonstrated that overexpression of SGK1 increased the current and expression level of the membrane localized mature proteins of hERG channels stably expressed in hERG-HEK293 cells."
26229434
reach
"Cui et al. found that an SGK1 activator, C4-ceramide, prevented those two drugs-induced hERG protein down-regulation (28)."
39386239
reach
"Therefore, we inferred that the SGK1 activation would rescue the downregulation of hERG channels in the cell membrane induced by nilotinib and vandetanib."
35680041