IndraLab

Statements

SGK1 activates KCNH2. 5 / 5
| 5
reach
"Consistent with the above observations, our data indicated that SGK1 activator effectively prevented nilotinib or vandetanib-induced the downregulation of hERG channels, thereby significantly reducing[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35680041
reach
"XREF_BIBR It has been demonstrated that overexpression of SGK1 increased the current and expression level of the membrane localized mature proteins of hERG channels stably expressed in hERG-HEK293 cells."
26229434
reach
"Cui et al. found that an SGK1 activator, C4-ceramide, prevented those two drugs-induced hERG protein down-regulation (28)."
39386239
reach
"Therefore, we inferred that the SGK1 activation would rescue the downregulation of hERG channels in the cell membrane induced by nilotinib and vandetanib."
35680041
reach
"HERG channel activity is up-regulated by the serum- and glucocorticoid inducible kinase isoforms SGK1 and SGK3."
23735862