IndraLab

Statements

Losartan inhibits KCNH2. 3 / 3
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"Losartan and eprosartan inhibited Kv11.1 channel repolarizing tail currents at 1 μM, whereas candesartan and, particularly, E3174 ( Figure 3 e) increased the maximum current and tail currents."
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"Losartan decreased HERG currents elicited at 0 mV (23.3 +/-4.8%), whereas E3174 increased the current (30.5 +/-6.2%)."
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"Furthermore, selective AT 1 receptor blocker losartan attenuates Ether-A-Go-Go Related Gene (HERG) currents (or I Kr), as well as prolongs the duration of APs and affects QT dispersion [XREF_BIBR]."
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