IndraLab

Statements

USP18 inhibits IL10. 2 / 3
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reach
"Supporting this hypothesis, we show that USP-18, a target of IRF-7 and known negative regulator of the type I interferon response, decreases the production of immune-regulatory cytokines IL-27 and IL-10."
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reach
"We show that IRF-7 siRNA knockdown enhanced LPS induced IL-10 production in human monocyte derived macrophages, and USP-18 overexpression attenuated LPS induced production of IL-10 in RAW264.7 cells."
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