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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

USP18 inhibits IL10. 2 / 3

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"Supporting this hypothesis, we show that USP-18, a target of IRF-7 and known negative regulator of the type I interferon response, decreases the production of immune-regulatory cytokines IL-27 and IL-10."

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"We show that IRF-7 siRNA knockdown enhanced LPS induced IL-10 production in human monocyte derived macrophages, and USP-18 overexpression attenuated LPS induced production of IL-10 in RAW264.7 cells."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...