IndraLab

"103 The mechanism suggests that USP25 induces endotoxin tolerance in KCs by removing the TRAF3 K48-linked ubiquitin chain thereby inhibiting its degradation and reducing the phosphorylation level of downstream JNK/P38, promoting the secretion of the inflammatory factor IL-10.Acrylamide in heated processed foods has attracted extensive attention because of its hepatotoxicity.104 Allicin is a plant-derived antioxidant which has a significant protective effect against acrylamide-induced hepatotoxicity, but its mechanism of action is not known.105 Steib et al studied the mechanism of action of allicin in KCs.106 Allicin was found to inhibit activation of MAPK and NF-κB pathways and downregulate phosphorylation of JNK, ERK, p38, p65, and nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IκBα)."