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BRCC3 binds HMGCR. 5 / 5
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"We further found an interaction between endogenous HMGCR and BRCC36 in Hep3B cells (Figure 3I)."
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"Thiolutin, an inhibitor of BRCC36, effectively suppressed the interaction between BRCC36 and HMGCR, leading to the inhibition of HCC growth."
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"Furthermore, the immunofluorescence (IF) assay demonstrated the interaction between BRCC36 and HMGCR (Figure 3J)."
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"This suggests that BRCC36 and HMGCR are negatively correlated with patient prognosis and could potentially serve as prognostic factors in HCC.2.7 Thiolutin Weakens the Interaction between BRCC36 and HMGCR and Inhibits Tumor Growth in HCC."
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"We further performed an IF assay to determine the interaction between HMGCR and BRCC36 in HepG2 cells treated with THL, and found that the interaction was attenuated (Figure 7B)."
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