IndraLab

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BRCC3 increases the amount of GSDMD. 2 / 2
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"50 BRCC36 overexpression upregulates GSDMD expression and induces chronic pyroptosis, both of which deteriorate the tumor microenvironment (TME) over time and accelerate tumor growth, but this needs to be further studied.Furthermore, THL could inhibit the activity of the BRCC36 enzyme, reduce HMGCR protein levels, and suppress tumor growth."
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"We also found that overexpression of BRCC36 increased the expression of NLRP3 and GSDMD (Figure 6I; Figure S6F, Supporting Information)."
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