IndraLab

Statements

Temozolomide decreases the amount of KCNH1. 2 / 2
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"Eag1 was highly expressed in human U87MG glioblastoma cells (CTCF, 19.65 +/-0.76; XREF_FIG) while TMZ and the pKv10.1-3 vector decreased this expression of Eag1 (XREF_FIG)."
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"p53 protein negatively regulates Eag1; therefore, we hypothesize that TMZ, at least indirectly, may reduce Eag1 expression, amplifying the drug effects on glioma cells."
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