IndraLab

Statements

USP22 activates pathway. 7 / 7
| 7
sparser
"USP22 activates PI3K/Akt/mTOR pathway via SIRT1/PTEN axis."
39135915
sparser
"To verify whether USP22 activates the SRC pathway by stabilizing KDELR1 expression, we overexpressed KDELR1 in H1299 and H1975 cells with USP22 knockdown and depleted KDELR1 in PC9 cells with USP22 overexpression."
39101247
sparser
"By up- and downregulation of USP22 expression, we also proved that USP22 can activate the Wnt/β-Catenin pathway, which in turn affected the proliferation and migration of HepG2 cells."
33090397
sparser
"SIRT1 has been reported to deacetylate PTEN and activate the PI3K/Akt/mTOR pathway. xref Deacetylated PTEN is well known to activate PI3K/AKT/mTOR pathway through promoting its phosphatase activity. xref , xref , xref To determine whether USP22 activates the PI3K/Akt/mTOR pathway via SIRT1‐mediated PTEN deacetylation, we used siRNA to silence the expression of SIRT1 in USP22‐overexpressing melanoma cells."
39135915
sparser
"These findings suggested that USP22 activates the PI3K/Akt/mTOR pathway and induces melanoma EMT via the SIRT1/PTEN axis."
39135915
sparser
"In CRC, because of the low expression of miR-30-5p, USP22 activates the Wnt/β-catenin pathway by increasing the nuclear concentration of β-catenin, and enhancing cancer stemness and tumorigenesis [ xref ]."
31861404
sparser
"Gene Set Enrichment Analysis (GSEA) further illustrated that USP22 markedly activates PI3K/Akt/mTOR pathway (Figure  xref )."
39135915