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USP22 activates pathway. 8 / 8
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"USP22 activates PI3K/Akt/mTOR pathway via SIRT1/PTEN axis."
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"To verify whether USP22 activates the SRC pathway by stabilizing KDELR1 expression, we overexpressed KDELR1 in H1299 and H1975 cells with USP22 knockdown and depleted KDELR1 in PC9 cells with USP22 overexpression."
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"By up- and downregulation of USP22 expression, we also proved that USP22 can activate the Wnt/β-Catenin pathway, which in turn affected the proliferation and migration of HepG2 cells."
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"SIRT1 has been reported to deacetylate PTEN and activate the PI3K/Akt/mTOR pathway. xref Deacetylated PTEN is well known to activate PI3K/AKT/mTOR pathway through promoting its phosphatase activity. xref , xref , xref To determine whether USP22 activates the PI3K/Akt/mTOR pathway via SIRT1‐mediated PTEN deacetylation, we used siRNA to silence the expression of SIRT1 in USP22‐overexpressing melanoma cells."
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"These findings suggested that USP22 activates the PI3K/Akt/mTOR pathway and induces melanoma EMT via the SIRT1/PTEN axis."
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"In CRC, because of the low expression of miR-30-5p, USP22 activates the Wnt/β-catenin pathway by increasing the nuclear concentration of β-catenin, and enhancing cancer stemness and tumorigenesis [ xref ]."
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"Deubiquitinase USP22 not only activates the SIRT1/AKT/MRP1 pathway to promote MDR, but also promotes HCC cancer stemness by HIF1α/USP22 positive feedback loop, leading to SOR resistance. xref , xref The lipid nanocomposite Gal-SLPs, loaded with shUSP22, were constructed by Xu et al xref to overcome SOR resistance ( xref )."
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"Gene Set Enrichment Analysis (GSEA) further illustrated that USP22 markedly activates PI3K/Akt/mTOR pathway (Figure  xref )."
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