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USP1 activates KDM4A. 3 / 3
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"We observed that the USP1 inhibitor promoted KDM4A degradation ( Figure7D ) ."
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"Taken together, these results suggest that USP1 directly regulates KDM4A stability."
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"Furthermore, we found that USP1 overexpression decreased the polyubiquitination levels in WT, K6R, K11R, K27R, K29R, K33R, and K63R HA-ubiquitin mutants but not in K48R mutant, suggesting USP1 promotes KDM4A K48 linked deubiquitin; however, which E3 ubiquitin ligase mediated KDM4A ubiquitin and degradation is still unclear."
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