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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP1 activates KDM4A. 3 / 3

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"We observed that the USP1 inhibitor promoted KDM4A degradation ( Figure7D ) ."

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"Taken together, these results suggest that USP1 directly regulates KDM4A stability."

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"Furthermore, we found that USP1 overexpression decreased the polyubiquitination levels in WT, K6R, K11R, K27R, K29R, K33R, and K63R HA-ubiquitin mutants but not in K48R mutant, suggesting USP1 promotes KDM4A K48 linked deubiquitin; however, which E3 ubiquitin ligase mediated KDM4A ubiquitin and degradation is still unclear."

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USP1 activates KDM4A. 3 / 3

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