IndraLab

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USP9X deubiquitinates BCL9. 4 / 4
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"Additionally, the deubiquitination of BCL9 by USP9X increases proliferation and invasion of breast cancer cells."
32486158
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"Here, using MCF-7, HeLa, HEK293T, MDA-MB-231, and Sf9 cells, along with immunoblotting and immunofluorescence, nano-HPLC-MS/MS, deubiquitination, immunoprecipitation, and chromatin immunoprecipitation (ChIP) assays, we report that <span class="match term1">BCL9</span> physically associates with a protein deubiquitinase, ubiquitin-specific peptidase 9, X-linked (<span class="match term0">USP9X</span>), and that <span class="match term0">USP9X</span> removes Lys-63-linked polyubiquitin on Lys-212 of <span class="match term1">BCL9</span>"
31073027
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"278 The deubiquitination of BCL9 by USP9X facilitates the assembly of the β-catenin-BCL9-PYGO complex, thereby augmenting the transcriptional activity of Wnt/β-catenin target genes."
40034124
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"The USP9X mediated BCL9 deubiquitination promotes formation of the beta, catenin, BCL9, and PYGO complex, increasing the transcriptional activity of the Wnt and beta-catenin target genes."
32486158