IndraLab

Statements

DDR inhibits USP28. 3 / 3
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"Overall, our research provides new insights into the DDR blocking effect, cellular toxicity mechanism, and proliferation inhibition mechanism of USP28 inhibition."
39222275
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"We propose that during an unperturbed cell cycle, DDR signaling due to endogenous DNA lesions or fork stalling can disrupt USP28 dimers to transiently activate USP28 for localized origin firing."
38227944
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"DDR signaling diminishes USP28 dimerization."
38227944