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UCHL5 deubiquitinates SMO. 3 / 3
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"UCHL5 could inhibit SMO ubiquitination and suppress PC-12 cell apoptosis during OGD/R."

"The deubiquitinase <span class="match term0">UCHL5</span>/UCH37 positively regulates Hedgehog signaling by deubiquitinating <span class="match term1">SMOOTHENED</span>"

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"We provide both genetic and biochemical evidence that UCHL5 interacts with and deubiquitinates Smo, increasing stability and promoting accumulation at the cell membrane."