IndraLab

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Lactate inhibits MAVS. 15 / 15
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"Lactate negatively regulates RLR-mitochondrial antiviral signaling protein (MAVS) signaling and following reactions.Figure 4: Interaction of lncRNA with RIG-I-MAVS pathway."
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"Another article reported that lactate is a natural suppressor of RLR signaling targeting MAVS (Zhang et al., 2019)."
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"Under physiological conditions, the interaction between hexokinase II (HK2), a key rate-limiting enzyme for glycolysis and located on the mitochondrial outer membrane, and MAVS maintains HK2 activity in its basal state, which ensures the operation of glycolysis metabolism and the suppression of MAVS mediated by lactate."
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"Another article reported that lactate is a natural suppressor of RLR signaling targeting MAVS ."
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"Excess lactate blocks the antiviral MAVS entry into the mitochondrion through the TOM70 pore."
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"Lactate directly inhibits MAVS resulting in reduced class I interferon production ( xref ) and in addition, exerts immunosuppressive effects (Ivashkiv,  xref )."
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"Inhibition of lactate generation by oxamate potentiated MAVS mitochondria localization, but lactate add-back compromised this effect (XREF_FIG and XREF_FIG)."
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"Lactate directly inhibits MAVS resulting in reduced class I interferon production (Zhang et al.,) and in addition, exerts immunosuppressive effects (Ivashkiv, 2020)."
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"As a second example, lactate, which is produced during aerobic glycolysis and has virus restricting activity XREF_BIBR, XREF_BIBR, also directly inhibits MAVS activity; thus lactate both reduces levels of viral PAMPs and has a negative regulatory function to inhibit PAMP driven signalling and interferon expression 128."
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"What is more, MAVS is inhibited by HK2 and lactate, while LncRNA may regulate HK2- or LDHA-dependent lactate production via upstream kinase stimulation."
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"What is more, MAVS is inhibited by HK2 and lactate, while LncRNA may regulate HK2- or LDHA-dependent lactate production via upstream kinase stimulation."
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"In addition, MAVS aggregation can be suppressed by lactate [78] and TRIM31 is known to bind with phosphotidyethanolamine [79]."
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"Also, lactate can directly interact with the mitochondrial antiviral-signaling (MAVS) protein, preventing MAVS aggregation and therefore reducing type I interferon production during RIG-I-like receptor (RLR) signaling (Zhang et al., 2019b)."
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"In order to unravel the underlying mechanism by which lactate inhibits RIG-I-MAVS induced RLR activation, we explored whether lactate impacts the mitochondria localization of MAVS by binding to its TM domain, ( xref )."
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"Lactate negatively regulates RLR-mitochondrial antiviral signaling protein (MAVS) signaling and following reactions."
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