IndraLab

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USP7 inhibits DNA methylation. 3 / 3
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"These results demonstrate that Usp7 can repress germline genes independently of DNA methylation in embryonic stem cells.We then asked if the long-term absence of USP7 impairs DNA methylation of germline genes by performing RRBS in Usp7 WT and KO ESC clones (Supplementary Table S3)."
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"The diagrams illustrate how USP7 suppresses excessive DNA methylation by DNMT1 to promote DNA methylation homeostasis ."
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"Consistent with this data, previous report also showed that the loss of USP7 in HeLa cells leads to the increase of DNA methylation in a substantial fraction of de novo DNA methylation sites upon long-term culture (Jialun et al., 2020)."
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