IndraLab

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Carnosol inhibits NLRP3. 16 / 16
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"These results suggested that carnosol blocks the activation of the NLRP3 and NLRC4 inflammasomes by binding to HSP90 and inhibiting its ATPase activity."
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"A high-throughput assay for bioluminescent caspase-1 activity in screening NLRP3 inflammasome inhibitors revealed that carnosol inhibits NLRP3 inflammasome activation (data not shown)."
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"Carnosol inhibits NLRP3 inflammasome activation in BMDMs, THP1 cells and hPBMCs."
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"Taken together, these results showed that carnosol treatment disrupts the activation of NLRP3 inflammasome and NLRP3 related septic shock in mice."
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"To test whether carnosol inhibits NLRP3 inflammasome activation in vivo, we chose the NLRP3 inflammasome dependent septic shock mouse model induced by intraperitoneal injection of LPS XREF_BIBR, XREF_BIBR."
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"Our data demonstrate that carnosol inhibits NLRP3 inflammasome activation in primary mouse bone marrow derived macrophages (BMDMs), THP-1 cells and human peripheral blood mononuclear cells (hPBMCs)."
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"In this study, we demonstrate that carnosol treatment inhibits NLRP3 inflammasome activation by directly interacting with HSP90 and blocking its ATPase activity."
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"More importantly, carnosol treatment prevents or alleviates NLRP3 inflammasome mediated diseases in mouse models, indicating that carnosol is a potential candidate for the treatment of inflammasome mediated human diseases."
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"Our data demonstrate that carnosol inhibits NLRP3 inflammasome activation in primary mouse bone marrow derived macrophages (BMDMs), THP-1 cells and human peripheral blood mononuclear cells (hPBMCs)."
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"Thus, these results demonstrate that carnosol treatment inhibits NLRP3 and NLRC4 inflammasome activation by blocking HSP90 and disrupting its ATPase activity."
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"Here, we report that carnosol inhibits NLRP3 inflammasome activation by directly targeting heat-shock protein 90 (HSP90), which is essential for NLRP3 inflammasome activity, thereby treating inflammasome mediated diseases."
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"Consistent with the effect of GA, our results showed that carnosol also blocked NLRP3 and NLRC4, but not AIM2 inflammasome activation."
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"Taken together, these results demonstrate that carnosol treatment inhibits the activation of the NLRP3 inflammasome."
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"Here, we report that carnosol inhibits NLRP3 inflammasome activation by directly targeting heat-shock protein 90 (HSP90), which is essential for NLRP3 inflammasome activity, thereby treating inflammasome mediated diseases."
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"We also demonstrated that carnosol can prevent or treat NLRP3 inflammasome driven human diseases, including septic shock and NASH in mouse models."
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"Although the initial effective dose of carnosol needed to inhibit NLRP3 inflammasome activation was higher than that of MCC950 in vitro, the rescue effect of carnosol on inflammasome related diseases was comparable to that of MCC950 in all tested animal models of human diseases, suggesting that carnosol has a therapeutic potential equivalent to that of MCC950 for inflammasome mediated diseases."
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