IndraLab

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USP18 increases the amount of SLC7A11. 3 / 3
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"Indeed, USP18 knockdown significantly reduced SLC7A11 levels in multiple human cancer lines (Fig. 4H and SI Appendix, Fig. S5C), but had moderate effects on SLC7A11 mRNA levels (Fig. 4I and SI Appendix, Fig. S5D)."
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"Moreover, USP18 overexpression increased SLC7A11 levels in a dose-dependent manner (Fig. 4J and SI Appendix, Fig. S5E)."
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"To further confirm the role of USP18 in regulating SLC7A11 turnover, we generated USP18 knockout MDA-MB-231 cells through the CRISPR-Cas9 approach, and found that USP18 deletion decreased SLC7A11 levels (SI Appendix, Fig. S5J), shortened its protein half-life (SI Appendix, Fig. S5 K and L), and increased the polyubiquitylation of SLC7A11 (SI Appendix, Fig. S5M)."
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