IndraLab

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USP7 activates NFE2L1. 6 / 6
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"Steady-state levels of bands corresponding to membrane-free (lower band) V5-tagged TCF11 and Nrf1a were significantly increased by overexpression of USP7-Flag in a dose-dependent manner (Fig. 2, D and E, left panels)."
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"Based on these results, we conclude that USP7 promotes stabilization of Nrf1 proteins in response to toxic metals."
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"Collectively, these findings suggest that USP7 may act to modulate abundance of Nrf1 protein to induce gene expression in response to toxic metal exposure."
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"Together, these results support the idea that USP7 can modulate Nrf1 function in cells.Our results show that TCF11 and Nrf1a proteins are stabilized by USP7 in response to arsenic and other heavy metals."
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"USP7 enhances TCF11- and Nrf1a-mediated transcriptional activation."
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"We show here that USP7 counteracts ubiquitination and promotes stabilization of Nrf1a and TCF11."
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