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Cloxyquin activates KCNK18. 3 / 3
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"In a different set of experiments, background currents were enhanced by arachidonic acid, a known activator of TREK-1/TREK-2/TRAAK, or by cloxyquin, that activates TRESK, allowing us to test the effects of TM in native cells."
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"Although high (100 μM) concentrations are required, cloxyquin has also been used to activate TRESK in vivo [33,34,35]."
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"We have investigated the mechanism of cloxyquin mediated TRESK activation, focusing on the differences between the physiologically relevant regulatory states of the channel."
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