IndraLab

Statements

OTUB2 activates AKT. 6 / 6
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"OTUB2 increases the activity of the glycolytic enzyme PGK1 and activates Akt/mTOR signalling pathways to promote the Warburg effect in NSCLC by stabilising U2AF2 [49] ."
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"Since OTUB2 can promote cancer progression by regulating Hippo, NF-kB and Akt/mTOR pathways , we next investigated the effects of OTUB2-IN-1 on regulating Hippo, NF-κB and Akt/mTOR pathways."
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"Based on these findings, we hypothesized that OTUB2 activates AKT by deubiquitinating TRAF6, thereby exerting a pro-oncogenic effect."
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"Inhibition of OTUB2 promotes apoptosis and attenuates proliferation and metastasis of CC cells by downregulating the AKT/mTOR signalling pathway (Ref."
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"The researchers also investigated the relationship between OTUB2 and KRT80 and the AKT pathway and found that both OTUB2 and KRT80 can activate the AKT pathway."
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"OTUB2 deubiquitinates TRAF6 and activates AKT."
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