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TNFAIP3 activates NLRP3. 6 / 6
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"In order to further confirm whether TNFAIP3 activates NLRP3 activation, a lentivirus carrying the TNFAIP3 gene (Len-TNFAIP3) was transfected into CMECs."
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"For example, Walle et al. showed that the negative regulation of NLRP3 inflammasome activation induced by A20 markedly protects against the onset of RA-associated inflammation and cartilage destruction, highlighting the contribution of the NLRP3 inflammasome to the pathology of RA [ xref ]."
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"Next, we investigated whether Becn1 modulates TNFAIP3 expression and activates NLRP3 activation."
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"Loss of TLR4 in endothelial cells increased TNFAIP3 levels, while decreasing NLRP3 pathway proteins."
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"Our data also concluded that overexpression of NLRP3 inflammasome exhibited promoting properties in AP via mechanisms involving inflammatory process, apoptosis, and oxidative stress, which could aboli[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Based on previous studies, TNFAIP3 may potentially modulate the RIP3/NLRP3 axis, therefore affecting the development of AP.The experiments involving animals were performed under approval of the Instit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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