IndraLab

Statements

PKC inhibits KCNH2. 6 / 6
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"Furthermore, broad-specificity inhibitors of protein kinase A (PKA) or protein kinase C (PKC) failed to stimulate hERG down-regulation in the presence or absence of ouabain (unpublished data), suggesting that glycoside induced down-regulation of hERG is independent of PKA- and PKC dependent phosphorylation."
24152733
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"Furthermore, broad-specificity inhibitors of protein kinase A (PKA) or protein kinase C (PKC) failed to stimulate hERG down-regulation in the presence or absence of ouabain (unpublished data), suggesting that glycoside induced down-regulation of hERG is independent of PKA- and PKC dependent phosphorylation."
24152733
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"Several papers have reported that either alpha-adrenergic or non selective PKC stimulation by PMA reduces hERG currents in cardiomyocyte."
22202075
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"Our results suggest that PKC may enhance hERG channel protein degradation via proteasomal pathway."
25218469
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"PKCα inhibited hERG channels downstream of α adrenoreceptor function likely through phosphorylation of T74 on its N terminus (100)."
35588786
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"Our results are similar to the results from previous studies, which suggested that in HEK293 cells, the intracellular pathways linking α -AR to hERG include the activation of Gq, PLC, PIP2, and PKC [22], and PKCα mediates hERG inhibition when α -AR is activated [40]."
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