IndraLab

Statements

PKC inhibits KCNH2. 4 / 4
| 4
reach
"Furthermore, broad-specificity inhibitors of protein kinase A (PKA) or protein kinase C (PKC) failed to stimulate hERG down-regulation in the presence or absence of ouabain (unpublished data), suggesting that glycoside induced down-regulation of hERG is independent of PKA- and PKC dependent phosphorylation."
24152733
reach
"Our results suggest that PKC may enhance hERG channel protein degradation via proteasomal pathway."
25218469
reach
"Furthermore, broad-specificity inhibitors of protein kinase A (PKA) or protein kinase C (PKC) failed to stimulate hERG down-regulation in the presence or absence of ouabain (unpublished data), suggesting that glycoside induced down-regulation of hERG is independent of PKA- and PKC dependent phosphorylation."
24152733
reach
"Several papers have reported that either alpha-adrenergic or non selective PKC stimulation by PMA reduces hERG currents in cardiomyocyte."
22202075