IndraLab

Statements

Mutated USP8 increases the amount of SSTR5. 3 / 3
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"Overexpressing USP8 mutants in a murine corticotroph tumour cell model increased endogenous somatostatin receptor 5 (Sstr5) transcription."
35686696
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"Thus, the potential influence of baseline radiotherapy treatment on the subsequent improved response to pasireotide LAR therapy cannot be entirely excluded.Ubiquitin-specific protease 8 (USP-8) gene mutational status could be a potential marker of the pasireotide response, as mutant USP8 forms may upregulate SSTR5 transcription [1,17,18]."
40283624
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"USP8 Mutants Upregulate SSTR5 Expression Levels in Primary Cultured Cells and AtT20 Cells."
35626057