IndraLab

Statements

Doxycycline inhibits COPS5. 8 / 8
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"In this in vitro system, doxycycline inhibited CSN5 catalyzed deneddylation with an IC 50 about 110 muM."
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"Thus, doxycycline selectively inhibits CSN5, instead of being a general inhibitor of the JAMM family, likely through a mechanism more than mere zinc chelation."
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"Collectively, the results support the idea that doxycycline inhibits CSN5 function in cultured DLBCL cells."
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"To investigate whether doxycycline indeed inhibits the activity of CSN5 in DLBCL cells, we examined the effect of doxycycline treatment on cullin neddylation."
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"Doxycycline accumulates in DLBCL cells and inhibits CSN5 function in these cells."
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"Doxycycline treatment resulted in an increase in the neddylated (slower migrating) forms of Cullin-1 and Cullin-2 in the DLBCL cells, indicating that doxycycline inhibits CSN5 activity in DLBCL cells."
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"Doxycycline inhibits CSN5 activity in vitro."
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"The fact that doxycycline inhibited CSN5 activity significantly in vitro only at relatively high drug concentrations (IC 50 : ~ 110 muM) thus raised the question whether the concentrations of doxycycline in the DLBCL cells under our experimental conditions were sufficient to inhibit CSN5 activity."
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