IndraLab

Statements

OTUD5 decreases the amount of PTEN. 2 / 2
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"Furthermore, we quantified the ubiquitination levels of PTEN in A549 and HCI-H460 cells and documented that OTUD5 overexpression reduced the ubiquitination level of PTEN (Figure 3D)."
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"Subsequent experimentation revealed that miR-652-3p inhibition brought about an increase in OTUD5 expression levels (p < 0.05, Figure 6B and C) and PTEN protein levels (p < 0.05, Figure 6D and E), while simultaneously reducing the ubiquitination level of PTEN, cell viability (p < 0.05, Figure 6F), and the number of migrated and invaded cells (p < 0.05, Figure 6G and H)."
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