IndraLab

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IRX5 decreases the amount of KCND2. 4 / 4
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"In mice, Irx5 is expressed in an endocardial-to-epicardial gradient and represses the expression of Kcnd2, a potassium channel carrying I , leading to low I magnitude in the subendocardium."
37216437
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"This model revealed that miR-1-2 might regulate protein abundance of IRX5, which represses transcription of KCND2 XREF_BIBR, encoding the potassium channel subunit Kv4.2 that encodes the cardiac transient outward potassium current I to, f XREF_BIBR."
25415383
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"It has been proposed that the homeodomain transcription factors Irx5 and Irx3 repress Kv4.2 expression [20,21] ."
21787784
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"Irx5 recruits the mBop cardiac corepressor to repress transcription of Kcnd2 in neonatal cardiomyocytes, and thus Irx5 deficiency leads to increased K v 4.2 expression and disruption of the I to gradient."
19797194