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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

IRX5 decreases the amount of KCND2. 2 / 2

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"Irx5 recruits the mBop cardiac corepressor to repress transcription of Kcnd2 in neonatal cardiomyocytes, and thus Irx5 deficiency leads to increased K v 4.2 expression and disruption of the I to gradient."

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"This model revealed that miR-1-2 might regulate protein abundance of IRX5, which represses transcription of KCND2 XREF_BIBR, encoding the potassium channel subunit Kv4.2 that encodes the cardiac transient outward potassium current I to, f XREF_BIBR."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...