IndraLab

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USP4 deubiquitinates TRAF6. 12 / 13
1 | 12
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"USP4 deubiquitinates TRAF2 and TRAF6, but not TRAF3, and it also rescues IkappaBalpha from degradation in TNFalpha induced HEK cells [XREF_BIBR]."
33138315
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"However, there is no evidence of how USP4 deubiquitinates TRAF6 and TRAF2 proteins; our results prove that USP4 targets TRAF6 for K48 linked deubiquitination."
30194441
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"For example, TNFAIP3, CYLD, USP3, USP4, USP15, USP25, and OTUD5 deubiquitinate key components of the IFN production pathway, including RIG-I, TRAF2, TRAF3, TRAF6, RIP1, and TRIF (reviewed in [93,94])."
38716888
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"These findings suggest that USP4 deubiquitinates TRAF6 largely in a noncatalytic manner."
30194441
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"Taken together, these findings suggest that USP4 decreases the polyubiquitination of TRAF6 in a ubiquitin specific domain dependent manner."
30194441
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"In colon cancer, a deubiquitinating enzyme USP4 suppressed anti-tumor immune responses by deubiquitinating TRAF6 and IRF3, hindering the nuclear localization of the latter protein and thus inhibiting cellular interferon responses and antigen presentation (Zhou et al., 2024)."
40183093
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"Animal studies have shown that USP4 expression in microglia cells decreases after SCI, leading to microglial activation and subsequent neuronal inflammation through NF-kB by attenuating the deubiquitination of TRAF6 [44]."
40125122
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"The results indicated that USP4 suppresses the nuclear localization of IRF3 by deubiquitinating IRF3 in CRC cells.It has been reported that USP4 interacted with and deubiquitinates TRAF6 [ 25 ], which[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38556105
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"USP4 interacts with and deubiquitinates TRAF6, thereby preventing the activation of NF-kappaB and AP-1 transcription factors and subsequent immune responses."
33511009
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"USP4 interacts with and deubiquitinates Lys-63-linked polyubiquitination of TRAF6, thereby suppressing the activation of NF-κB and TLR/IL-1R-mediated innate immune responses [ 21 ]."
38556105
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"Interestingly, USP4 deubiquitinates not only TRAF2 but also TRAF6 and leads to the regulation of cell migration [12]."
| PMC
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"USP4 deubiquitinates TRAF6 and thereby prevents the activation of NF-kappaB and AP-1 transcription factors and subsequent proinflammatory responses."
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