IndraLab

Statements

eidos
"To investigate the molecular mechanisms by which USP13 modulates ECM expression , we focused on the role of USP13 on Smad4 expression ."
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"The results indicate that USP13 promotes ECM expression by stabilizing Smad4 in lung fibroblasts and plays a role in the maintenance of the extracellular matrix in lungs ."
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"We used a mild CS exposure system and found that USP13 deficiency caused loss of extracellular matrix , increased lung inflammation and enlargement of alveolar spaces in response to CS exposure ."
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"28 In this study , we identify that USP13 promotes ECM expression by stabilizing Smad4 in lung fibroblast cells ."
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"Taken together , USP13 deficiency causes loss in extracellular matrix levels in lungs , thereby enlarging alveolar space in response to CS exposure ."
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