IndraLab

Statements

BAP1 is phosphorylated. 59 / 59
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"(e) Exogenous BAP1 increased both BRCA1 protein and its phosphorylation levels."
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"Irradiation of MM cells induces phosphorylation of BAP1."
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"Such dissociation of DUBs induced by ATM-dependent phosphorylation has been reported for another UCH family DUB, BAP1, the substrate of which is ubiquitylated H2A. Phosphorylation of BAP1 that promotes HR resulted in reduced chromatin binding of BAP1 xref ."
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"Moreover, ODN-induced mitochondrial ROS generation was involved in DNA damage, BAP1 phosphorylation, upregulation of Sp1 and Bax, sensitization of anti-cancer drug-mediated apoptosis."
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"Analysis of the BAP1 phosphorylation sites showed that the S292 locus of BAP1 had a higher phosphorylation level in most cancers (all p < 0.01, except for renal clear cell carcinoma), followed by locu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35905855
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"PLK-3-mediated phosphorylation of BAP1 prevents diabetic retinopathy."
38906226
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"First, when MeT-5A cells, which harbor WT BAP1 , were irradiated, we observed the strongest BAP1 phosphorylation level 1 h after IR, which then gradually decreased (Fig. xref )."
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"In this matter, the regulation of its ubiquitination and the activity of the kinases responsible for BAP1 phosphorylation are not well defined and could be altered in the tumoral context."
27057633
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"After IR, we found that both WT and mutant BAP1 were similarly phosphorylated and phospho-BAP1 localized mainly in the nucleus."
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"Q209L and BAP1 p."
40316673
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"Eletr et al . xref reported that BAP1 is phosphorylated at serine 592 following DNA damage, that phospho-BAP1 causes deubiquitination of H2AK119ub1, and that this signal promotes the HR pathway."
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"Our results suggest reciprocal positive interactions between BAP1 and DNA-PKcs, based on phosphorylation of BAP1 by the latter and deubiquitination of DNA-PKcs by BAP1."
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"Additionally, BAP1 can be phosphorylated by multiple DNA damage-responsive kinases in response to genotoxic stress, facilitating its recruitment to sites of DNA double-strand breaks, where it regulates H2Aub levels and ensures the efficient assembly of DNA damage repair factors such as BRCA1 and RAD51 ( xref )."
40644555
rlimsp
"In this matter, the regulation of its ubiquitination and the activity of the kinases responsible for BAP1 phosphorylation are not well defined and could be altered in the tumoral context."
27057633
rlimsp
"Irradiation of MM cells induces phosphorylation of BAP1."
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"Mito-TEMPO pretreatment inhibited ODN-induced BAP1 phosphorylation, increased Bax expression, and promoted apoptosis induced by the combined treatment of ODN and oxaliplatin ( xref , xref E)."
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"Next, we analyzed the BAP1 protein phosphorylation levels between primary tumor tissues and their normal controls using the CPTAC dataset."
35905855
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"R1000*(PLS = 3 UPD/LOH), and BAP1 p."
36369599
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"These results suggested that BAP1 is phosphorylated after DNA damage in a mitochondrial ROS-dependent manner."
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"Additionally, it was intriguing to find that phosphorylation of mutant BAP1 seemed to induce its translocation from the cytoplasm to the nucleus, as Western blot analysis detected strong p-S592 BAP1 in the nucleus of the mutant F679LfsX37-transduced cells (Fig. xref , second lane from the right)."
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"Irradiation (IR) induces phosphorylation of BRCA1-associated protein 1 (BAP1)."
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"In addition, the exact role of BAP1 phosphorylation in DSB repair remains unknown and certainly needs to be clarified."
37009801
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"The phosphorylation of BAP1 and its catalytic activity are necessary prerequisites for its repair function ( xref )."
36380871
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"Mitochondrial ROS production is critical for ODN-mediated DNA damage and BAP1 phosphorylation."
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"In addition, the Wilkinson lab showed that following DNA damage, BAP1 becomes phosphorylated at serine 592 xref , which matches the consensus sequence for the ATM/ATR DDR kinases."
32201366
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"BAP1 was tyrosine-phosphorylated in vivo, but the tyrosine phosphorylation of BAP1 was not correlated with its localization."
11056006
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"Collectively, this study shows that PLK-3 alleviates retinal vascular dysfunction in DR by inhibiting the phosphorylation of BAP1."
38906226
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"Interestingly, BAP1 phosphorylation is cell cycle regulated, with a peak of modification at the G1/S transition."
32201366
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"Interestingly, the Mito-TEMPO and NAC markedly inhibited ODN- and cathepsin K siRNA-induced BAP1 phosphorylation and Sp1 and Bax upregulation ( xref D)."
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"Evidence suggests that BAP1 phosphorylation is important for DSB repair."
37009801
rlimsp
"(b) BAP1 phosphorylation levels increased in proportion to IR doses."
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"Recruitment to DNA double-strand break sites is mediated via phosphorylation of BAP1, and the role of BAP in DNA damage response involves its catalytic activity [ xref ]."
34067960
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"BAP1 phosphorylation and its own catalytic activity are required for its recruitment to double-strand DNA break lesions and promotion of DNA repair by homologous recombination [ xref ]."
30897782
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"In the presence of DNA damage, PI3K-related kinases (ATM, ATR, and DNA-PKcs) phosphorylate BAP1 at Ser 592 to increase its recruitment on the site of DNA damage and facilitate proper DNA repair [ xref , xref ]."
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rlimsp
"After IR, we found that both WT and mutant BAP1 were similarly phosphorylated and phospho-BAP1 localized mainly in the nucleus."
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"Interestingly, ODN-mediated mitochondrial ROS production induced BAP1 phosphorylation, DNA damage, and Bax upregulation."
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"BAP1 is phosphorylated in response to DNA damage. xref , xref Both γ-radiation, which causes double stand DNA breaks, as well as UV-radiation, which causes DNA adducts, induces BAP1 phosphorlation. xref , xref While the role of BAP1 in the DNA damage response is unclear, several ubiquitin ligases (including BRCA1 and PRC1), and DUBs, accumulate at sites of DNA breaks, and gene expression is suppressed. xref , xref In addition, BAP1 depletion has been postulated to increase sensitivity to ionizing radiation. xref "
23867514
rlimsp
"We initially thought that this observation might have resulted from active transportation of phosphorylated BAP1 protein."
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"The BAP1 phosphorylation mutant exhibited no apparent defects in protein complex assembly or nucleosomal H2A deubiquitination in vitro xref ."
37009801
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"We initially thought that this observation might have resulted from active transportation of phosphorylated BAP1 protein."
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"However, we currently think that this observation does not necessarily reflect nuclear transport of the phosphorylated mutant BAP1."
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"Indeed, after UV irradiation, BAP1 is phosphorylated at multiple sites, including at Ser592 xref , xref ."
37009801
rlimsp
"Additionally, it was intriguing to find that phosphorylation of mutant BAP1 seemed to induce its translocation from the cytoplasm to the nucleus, as Western blot analysis detected strong p-S592 BAP1 in the nucleus of the mutant F679LfsX37-transduced cells (Fig.4d, second lane from the right)."
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"As a fraction of the F679Lfs37X BAP1 mutant protein resides in the nucleus (Fig. xref , fourth lane from the right), even if much less abundant than in the cytoplasm, the remarkably increased p-S592 BAP1 signal of F679Lfs37X may just reflect the phosphorylation of the mutant BAP1 that has been localized in the nucleus from the beginning."
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rlimsp
"As a fraction of the F679Lfs37X BAP1 mutant protein resides in the nucleus (Fig.4d, fourth lane from the right), even if much less abundant than in the cytoplasm, the remarkably increased p-S592 BAP1 signal of F679Lfs37X may just reflect the phosphorylation of the mutant BAP1 that has been localized in the nucleus from the beginning."
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"The role of BAP1 phosphorylation by ATM and possibly by ATR under replication stress conditions is still unknown and needs to be addressed in future studies."
37009801
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"BAP1 is phosphorylated on six serine/threonine residues following ionizing radiation and mutation of these residues inhibits BAP1 recruitment to DSB sites."
35764170
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"ODN induces Bax upregulation via BAP1 phosphorylation."
35584569
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"We investigated whether ODN modulates BAP1 phosphorylation."
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"However, whether BAP1 phosphorylation involves DUB conformational changes or recruitment of additional proteins remain to be determined."
35764170
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"It is known that stresses causing DNA DSBs, such as ionizing radiation, trigger BAP1 phosphorylation, assembly of the homologous recombination factors BRCA1 and RAD51, recruiting chromatin in the proximity of damaged sites [59,60]."
26166446
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"In addition, with immunofluorescence analysis, the strong phosphorylation of the exogenously transduced WT BAP1 into the MM cell with BAP1 deletion was also observed in the nucleus after IR exposure, in the same manner as with endogenous BAP1 (Fig. xref )."
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"It can phosphorylate and activate the deubiquitinase BAP1, leading to stabilization of the tumor suppressor pVHL and inhibiting tumor progression [ xref ]."
41268687
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"Therefore, it is possible that upon DNA damage, BAP1 is phosphorylated and its function modified to mediate growth suppression."
30669483
rlimsp
"Yu et al.26 also found six irradiation (IR)-induced phosphorylation sites in BAP1 and showed that mutation of these residues inhibits the recruitment of BAP1 to the double-strand break (DSB) sites."
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"BAP1 is phosphorylated following DNA damage and we asked whether BAP1 loss affected the response to γ-irradiation."
22683710
rlimsp
"Therefore, it is possible that upon DNA damage, BAP1 is phosphorylated and its function modified to mediate growth suppression."
30669483
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"BAP1 is phosphorylated following DNA damage xref , xref and we asked whether BAP1 loss affected the response to γ-irradiation."
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"By using immunofluorescence staining, we confirmed that phospho-BAP1 colocalized with Sp1 in the nucleus in ODN-treated Caki-1 cells ( xref E)."
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