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COPS5 inhibits CRL. 2 / 2

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"CSN is regulated by auto-inhibition, which is only released upon binding of NEDDylated CRL to ensure that CSN5 specifically inhibits the active NEDDylated CRLs [127] ."

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"All CRLs are inhibited by the COP9 signalosome complex (CSN) through both enzymatic (deneddylation) and nonenzymatic (steric) mechanisms."

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IndraLab

Statements

COPS5 inhibits CRL. 2 / 2

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