IndraLab

Statements

Modified USP13 leads to the dephosphorylation of AKT. 2 / 2
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"Loss of USP13 in breast cancer cells promotes AKT phosphorylation, cell proliferation, anchorage independent growth, glycolysis and tumor growth through downregulation of PTEN."
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"This overexpression upregulated PTEN protein and downregulated AKT and FOXO1/3 phosphorylation in the MDAMB-231 cell line (XREF_FIG) which expresses moderate but detectable levels of endogenous PTEN (XREF_SUPPLEMENTARY), while knockdown of PTEN in USP13 overexpressing MDA-MB-231 cells rescued the phosphorylation of both AKT and FOXO1/3 (XREF_SUPPLEMENTARY)."
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