Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP1 activates Genomic Instability. 2 / 2

| 2

➶

reach

"It is tempting to speculate that USP1 deficiency preferably produces replication stress and genomic instability at fragile sites."

27160904

➶

reach

"Interestingly, siRNA mediated knock-down of FAN1 and USP1, the enzyme responsible for deubiquitylating PCNA, caused similar genomic instability in U2OS cells, but the number of DSBs in the double knock-down was increased approximately two-fold, thus indicating that an increase in ub-PCNA may worsen the genomic instability in FAN1 depleted cells."

29051491

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...