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USP1 activates Genomic Instability. 2 / 2

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"Interestingly, siRNA mediated knock-down of FAN1 and USP1, the enzyme responsible for deubiquitylating PCNA, caused similar genomic instability in U2OS cells, but the number of DSBs in the double knock-down was increased approximately two-fold, thus indicating that an increase in ub-PCNA may worsen the genomic instability in FAN1 depleted cells."

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"It is tempting to speculate that USP1 deficiency preferably produces replication stress and genomic instability at fragile sites."

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USP1 activates Genomic Instability. 2 / 2

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