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USP15 deubiquitinates SMURF2. 7 / 7
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"USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination"
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"In light of the data presented so far we reasoned that USP15 may also directly deubiquitinate SMURF2."
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"We now establish that USP15 also directly deubiquitinates the E3 ligase SMURF2, opposing the activity of SMURF2 towards the TbetaR complex."
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"Here, we demonstrate that apart from targeting the TbetaR complex directly, USP15 also deubiquitinates SMURF2 resulting in enhanced TbetaR stability and downstream pathway activation."
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"Our results indicate that USP15 directly deubiquitinates SMURF2 potentially resulting in the inhibition of SMURF2 catalytic activity."
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"Eichhorn and co-workers found that USP15 not only targets the TGF-beta type I receptor complex but also deubiquitinates Smurf2."
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"To see if USP15 deubiquitinated SMURF2 in vitro, we purified USP15 and Ub-SMURF2 from extracts of HEK293T cells and proteins were mixed under conditions supporting SMURF2 deubiquitination."
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