IndraLab

Statements

COPS5 activates SMAD4. 3 / 3

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"Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation."

11818334

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"By degrading Smad4 or Smad7, Jab1 can repress or increase TGF-beta and BMP signaling, respectively, in vitro."

24604556

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"Our data suggest that Jab1 antagonizes TGF-beta function by inducing degradation of Smad4 through a distinct degradation pathway."

11818334

INDRA sources:

Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

COPS5 activates SMAD4. 3 / 3

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