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USP50 inhibits TP53BP1. 3 / 3
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"Moreover, 53BP1 foci were suppressed in shUSP50-expressing cells by additional expression of FLAG-USP50 but not by the I141R-FLAG-USP50 mutant (Fig. 2F)."
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"These data show both human and murine USP50 can act to suppress 53BP1 accumulations, implying a conserved role for USP50 in promoting replication.To address whether USP50 is relevant to the survival of cells experiencing replicative stress, we examined the ability of shUSP50-expressing cells, complemented with FLAG-USP50, to form colonies after exposure to HU."
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"In summary, in USP50-depleted cells, RECQL4, RECQL5 and DNA2 show aberrant localisation, suppress ongoing replication and promote spontaneous 53BP1 foci, they also suppress restart and increase ssDNA following exposure to HU."
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