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CTNNB1 increases the amount of sumoylated LEF1. 1 / 1

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"LEF-1 and TCF-4 sumoylation (by the SUMO ligase PIASy) represses LEF-1 activity by targeting it to nuclear bodies but enhances TCF-4 and beta-catenin transcription, while CBP mediated acetylation of TCF results in decreased TCF and beta-catenin-binding in Drosophila and increased TCF nuclear retention in nematodes, both leading to transcriptional repression."

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IndraLab

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CTNNB1 increases the amount of sumoylated LEF1. 1 / 1

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