IndraLab

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ATP inhibits NFKBIA. 3 / 3
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"ATP has no effect on the binding of an IkappaBalpha peptide for the rhIKK-1 and rhIKK-2 heterodimer (alpha = 0.99), whereas the binding of ATP decreased the affinity of the IkappaBalpha peptide for both rhTBK-1 (alpha = 10.16) and rhIKK-i (alpha = 62.28)."
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"19 Given the essential role of ATP dependent proteosomal degradation of IkappaBalpha, XREF_BIBR, XREF_BIBR - XREF_BIBR we propose that the protective effect of epoxomicin on importins turnover in stimulated cells implies a similar mechanism of proteosomal degradation."
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"16 When inflammatory signaling is induced, IkappaBalpha is rapidly degraded by proteasomes in an ATP dependent manner."
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