IndraLab

Statements

KCNH3 binds PIK3C3. 4 / 4
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"To exclude the possibility that 5-FU-induced autophagy could be an artefact of the transgenic reporter system used, we monitored the expression of the endogenous VPS-34 protein (a homologue of human class III PI3K) that interacts with BEC-1 ( xref )."
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"Loss-of-function of components of the autophagy pathway, including the VPS-34 and BEC-1 complex, causes accumulation of PGL-1 and PGL-3 into aggregates in somatic cells (termed PGL granules)."
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"Loss of sorf-1 or sorf-2 did not affect the BEC-1 and VPS-34 interaction, because similar levels of Flag-VPS-34 were coprecipitated with BEC-1 in N2, sorf-1 (tm3855), and sorf-2 (tm5210) animals (XREF_FIG)."
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"In C. elegans , BEC-1 interacts with the class III PI3 kinase VPS-34 (LET-512) [ xref ], an essential protein required for autophagy, membrane trafficking and endocytosis."
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