IndraLab

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PARD3 decreases the amount of USP28. 3 / 3
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"Previous studies have reported that Pard3 can regulate the stability of Snail1, however there is no clear report on whether Pard3 can regulate the expression of MMP9 by regulating the stability of Snail1.In this study we found that Pard3 silencing activated the NFκB pathway and promoted the transcription of USP28."
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"In addition, Pard3 silencing was found to increase the transcription of USP28 by activating the NFκB pathway.DUBs encompass approximately 90 cysteine proteases and metalloproteases, all of which play an important role in deubiquitinating and stabilizing target proteins [36]."
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"Moreover, Pard3 silencing led to activation of the NFkappaB pathway, promoting the expression of USP28."
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