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Thapsigargin activates KCNH2. 3 / 3
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"In a later study, the sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase inhibitor thapsigargin was also found to rescue two trafficking defective hERG mutants, G601S and F805C, also without causing hER[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Brian et al. found that thapsigargin could selectively rescue the transfer deficit of hERG potassium channels caused by Gly601Ser and Phe805Cys mutations, and the hERG blocker E4031 could repair defic[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Interestingly, Delisle et al reported that the sarco and endoplasmic reticulum ATPase inhibitor thapsigargin can rescue trafficking of mutated hERG channels possibly through altered Ca 2+ -dependent chaperone activity in the ER XREF_BIBR."
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