IndraLab

Statements

Modified COPS5 decreases the amount of CDKN1B. 5 / 5
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"Loss of Jab1 increases p27 levels in Schwann cells, which causes defective cell cycle progression and aberrant differentiation."
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"To investigate whether Jab1 overexpression in NPC cells downregulates p27 levels, we transduced those two cell lines with Jab1 adenovirus in the absence or presence of doxycycline and measured Myc-JAB and p27 levels 48 hours after infection."
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"Our findings suggest that Jab1 expression is inversely correlated with p27 expression levels, suggesting that Jab1 overexpression contributes to pathogenesis of OSCC by degradating p27 expression."
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"Fig. 3 shows that as previously reported, over-expression of Jab1 decreased p27 expression."
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"In breast cancer, hepatocellular carcinoma, and pancreatic adenocarcinoma, JAB1 is a negative regulator of p27, and high JAB1 expression is associated with poor prognosis and decreased p27 expression."
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