IndraLab

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Calcitriol decreases the amount of KCNH1. 12 / 14
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"For instance, calcitriol, the active metabolite of vitamin D with known antiproliferative effects, down-regulates Eag1 expression in breast tumor derived cells and in cervical cancer [XREF_BIBR, XREF_BIBR]."
22778627
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"In fact, this is the first time that inhibition of the oncogenic potassium channel Eag1 expression by calcitriol is reported."
19932096
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"Calcitriol inhibited Eag1 gene expression in MDA-MB-231 cells, but to a lesser extent of that seen in breast tumor derived cells."
19932096
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"As depicted in XREF_FIG, calcitriol or astemizole alone slightly reduced Eag1 and Ki-67 gene expression in IDC-1; however, when used concomitantly, a significant inhibition of gene expression was observed for both genes."
22984610
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"In this regard, evidence has been provided showing that the expression of KCNH1 is significantly inhibited by calcitriol in vitro in different types of breast and cervical cancer cells and in vivo in human breast cancer tumors xenografted in athymic mice [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
26102214
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"RT real-time PCR and immunocytochemistry showed that calcitriol suppressed Eag1 expression by a vitamin D receptor (VDR)-dependent mechanism."
19932096
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"Calcitriol dose-responsively inhibited Eag1 and Ki-67 gene expression in both cell lines (P < 0.05, XREF_FIG)."
22984610
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"Previously, our laboratory showed that EAG1 expression and the rate of cell proliferation are inhibited in breast and cervical cancer cells by calcitriol, the active vitamin D metabolite [XREF_BIBR, XREF_BIBR]."
25280486
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"In this study we tested a possible synergistic effect of the antihistamine astemizole, which inhibits Eag1 currents by selectively binding to open channels; and calcitriol, which inhibits Eag1 express[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19932096
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"As shown in Figure XREF_FIG, calcitriol per se significantly downregulated tumor EAG1 gene expression, which was further reduced when calcitriol and astemizole were administrated simultaneously."
25280486
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"Previously, we have shown that hEAG1 expression is downregulated by calcitriol in a variety of cancer cells."
25495694
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"Inhibition of Eag1 mRNA expression by calcitriol was also corroborated in MDA-MB-231 cells, which further supported our observations in tumor derived cells."
19932096