IndraLab

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Calcitriol decreases the amount of KCNH1. 14 / 16
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"In fact, this is the first time that inhibition of the oncogenic potassium channel Eag1 expression by calcitriol is reported."
19932096
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"In this regard, evidence has been provided showing that the expression of KCNH1 is significantly inhibited by calcitriol in vitro in different types of breast and cervical cancer cells and in vivo in human breast cancer tumors xenografted in athymic mice [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
26102214
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"Calcitriol inhibited Eag1 gene expression in MDA-MB-231 cells, but to a lesser extent of that seen in breast tumor derived cells."
19932096
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"Inhibition of Eag1 mRNA expression by calcitriol was also corroborated in MDA-MB-231 cells, which further supported our observations in tumor derived cells."
19932096
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"As shown in Figure XREF_FIG, calcitriol per se significantly downregulated tumor EAG1 gene expression, which was further reduced when calcitriol and astemizole were administrated simultaneously."
25280486
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"Calcitriol dose-responsively inhibited Eag1 and Ki-67 gene expression in both cell lines (P < 0.05, XREF_FIG)."
22984610
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"In this study we tested a possible synergistic effect of the antihistamine astemizole, which inhibits Eag1 currents by selectively binding to open channels; and calcitriol, which inhibits Eag1 express[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19932096
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"Previous research has demonstrated that calcitriol can downregulate the expression of EAG1 mRNA and protein in SiHa cells, leading to reduced proliferation."
38230221
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"Further studies on SiHa and C33A cells have revealed that calcitriol inhibited EAG1 gene expression at the transcriptional level, with the involvement of VDR 74.Various studies have reported that estrogen could play a role as a co-factor in the increased risk of cervical cancer in women with HPV DNA 75."
38230221
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"For instance, calcitriol, the active metabolite of vitamin D with known antiproliferative effects, down-regulates Eag1 expression in breast tumor derived cells and in cervical cancer [XREF_BIBR, XREF_BIBR]."
22778627
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"In contrast, calcitriol, the hormonally-active form of vitamin D3, decreases Kv10.1 expression [50] through a negative vitamin D-response element located in the KCNH1 promoter [74]."
35955591
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"As depicted in XREF_FIG, calcitriol or astemizole alone slightly reduced Eag1 and Ki-67 gene expression in IDC-1; however, when used concomitantly, a significant inhibition of gene expression was observed for both genes."
22984610
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"Previously, we have shown that hEAG1 expression is downregulated by calcitriol in a variety of cancer cells."
25495694
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"Previously, our laboratory showed that EAG1 expression and the rate of cell proliferation are inhibited in breast and cervical cancer cells by calcitriol, the active vitamin D metabolite [XREF_BIBR, XREF_BIBR]."
25280486